Air Pollution As A Major Health Hazard

Professionals are now recommending limiting physical activity in heavily polluted regions such as certain South Asian cities and China. Peshawar, Lahore, Karachi, Delhi, Mumbai, Beijing are highly polluted and it can lead to major health hazards.

Air pollution impairs the function of blood vessels in the lungs, according to a study in more than 16,000 patients presented today at EuroEcho-Imaging 2016.1

Promoting a safer environment appears to be as important as controlling conventional risk factors, like high cholesterol, in reducing cardiovascular disease.2 Air pollution consists of particles (particulate matter [PM] of different sizes) and gases (nitrogen dioxide, ozone, etc). The first vascular bed in contact with air pollutants is the pulmonary circulation yet few studies have investigated the impact.

“Such studies are important because if air pollution causes narrowing of the blood vessels in the lungs (vasoconstriction), this combined with the systemic effects of pollution could cause decompensated heart failure,” said Dr Argacha.

The current study examined the effect of air pollution on pulmonary haemodynamics in a population and in individuals. The population study assessed whether common levels of outdoor air pollution influence the echocardiography parameters conventionally used to evaluate the pulmonary circulation and right ventricular function.3 Between 2009 and 2013, transthoracic echocardiography including an evaluation of pulmonary pressure was conducted in 16 295 individuals and correlated with average air pollution in Brussels on the same day and in the last five and ten days.4 The authors examined whether any patient subgroups were more susceptible to the effects of air pollution.

The individual study examined the effect of air pollution on pulmonary circulation in ten healthy male volunteers exposed to pollutants in a chamber with standardized conditions. The volunteers were exposed to ambient air or dilute diesel exhaust with a PM2.5 concentration of 300 ?g/m3 for two hours in a randomized, crossover study design. The effects on pulmonary vascular resistance were assessed with echocardiography at rest and during a cardiac stress test in which the drug dobutamine is given to simulate heart function during exercise.

The population study showed a negative effect of PM10, PM2.5 and ozone on pulmonary circulation on the same day and over five and ten days. Specifically, increases in these pollutants were associated with reduced pulmonary acceleration time and increased pulmonary acceleration slope. Increases in PM10 and PM2.5 over ten days were associated with worse right ventricle function. The negative impact of PM10 on pulmonary circulation was more pronounced in patients with obstructive sleep apnea.

Dr Argacha said: “Air pollution was associated with increased pulmonary vascular tone which makes it more difficult for blood to flow to the lungs. Longer exposure to air pollution exposure seems necessary to impair right ventricular systolic function. Patients with obstructive sleep apnea were at greater risk.”

The individual study showed that exposure to diesel exhaust did not modify the pulmonary circulation compared to ambient air when the volunteers were resting but did when dobutamine was administered. “This suggests that pollution is more harmful to the lung circulation during exercise,” said Dr Argacha.

He continued: “Our dual approach provides original data on the impact of air pollution on the pulmonary circulation. The individual study strengthens the plausible link emerging from the epidemiological research.”

Regarding how to minimize the health risks, Dr Argacha said: “Our main advice is to limit physical activities during heavy air pollution. More studies are needed before specific recommendations on intensity and duration of exercise can be given. Emission controls such as particulate filters have reduced tailpipe emissions, but other sources such as engine crankcases, tires and brake wear are becoming important. No strong evidence exists on effectiveness of face masks to eliminate or reduce particle exposure.”

He added that legislation protecting the population from air pollution is weak. He said: “Diesel emission control has been associated with health outcomes5 but unfortunately the standards defined by the European Union differ from those of the World Health Organization.”6


1The abstract ‘Acute effects of air pollution on pulmonary hemodynamics: new evidence from both population and individual level studies’ will be presented during the Rapid Fire Abstract session ‘Great cardiac arteries pathology’ on 9 December, 11:00 to 12:30 CET in the Agora.

2Newby DE, et al. Expert position paper on air pollution and cardiovascular disease. Eur Heart J. 2015;36:83-93b. doi: 10.1093/eurheartj/ehu458.

3Pulmonary haemodynamic parameters included pulmonary acceleration time, pulmonary acceleration slope and maximal tricuspid regurgitation velocity. Markers of right ventricular systolic function included tricuspid annular plane systolic excursion (TAPSE).

4The average exposure of the Brussels population to particulate matter, nitrogen dioxide and ozone was calculated from a fixed monitoring station and compiled in a database by the Belgian Interregional Environment Agency.

5Yorifuji T, et al. Fine-particulate air pollution from diesel emission control and mortality rates in Tokyo: A quasi-experimental study. Epidemiology. 2016;27:769-778.

6The 2005 World Health Organization (WHO) recommendations on air pollution levels were set for PM2.5 at a maximal daily mean concentration of 25 μg/m3 and a maximal annual mean concentration of 10 μg/m3. European Union (EU) standards from 2008 differ from those of the WHO, with no recommendation for daily exposure and an annual mean concentration set at 25 μg/m3. Consequently in Belgium the WHO’s daily mean concentration for PM2.5 is exceeded 17.5% of days, but the annual mean level of PM2.5 remains below the recommended value from the EU.

Partial Reporting ScienceDaily

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